GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THYM | cis | rs9309473 | 1 | rs2056486 | chr2:73717567 | ALMS1P | chr2:73872046-73912692:+ | 0.58 | 4.75 | 7.12E-6 | Metabolite levels |
| THYM | cis | rs10935120 | 1 | rs2056603 | chr3:134312749 | ANAPC13 | chr3:134196547-134204865:- | 0.57 | 7.57 | 2.35E-11 | Height |
| THYM | cis | rs10935120 | 1 | rs2056603 | chr3:134312749 | CEP63 | chr3:134204575-134293852:+ | 0.42 | 6.06 | 2.7E-8 | Height |
| THYM | cis | rs10935120 | 1 | rs2056604 | chr3:134312648 | ANAPC13 | chr3:134196547-134204865:- | 0.55 | 7.48 | 3.7E-11 | Height |
| THYM | cis | rs10935120 | 1 | rs2056604 | chr3:134312648 | CEP63 | chr3:134204575-134293852:+ | 0.43 | 6.36 | 7.09E-9 | Height |
| THYM | cis | rs2058059 | 1 | rs2058059 | chr7:72311817 | TYW1B | chr7:72023729-72298813:- | -0.53 | -4.45 | 2.34E-5 | Subcutaneous adipose tissue |
| THYM | cis | rs7072122 | 1 | rs2067852 | chr10:45056521 | ZNF22 | chr10:45496273-45500776:+ | 0.64 | 5.71 | 1.28E-7 | Estradiol plasma levels (breast cancer) |
| THYM | cis | rs703842 | 1 | rs2069502 | chr12:58144665 | FAM119B | chr12:58166383-58176323:+ | -0.37 | -4.86 | 4.67E-6 | Multiple sclerosis |
| THYM | cis | rs703842 | 1 | rs2069502 | chr12:58144665 | TSFM | chr12:58176536-58191367:+ | 0.25 | 4.36 | 3.35E-5 | Multiple sclerosis |
| THYM | cis | rs3772130 | 1 | rs2070180 | chr3:121351338 | IQCB1 | chr3:121488610-121553926:- | -0.47 | -4.4 | 2.82E-5 | Cognitive performance |
| THYM | cis | rs703842 | 1 | rs2072052 | chr12:58146719 | FAM119B | chr12:58166383-58176323:+ | 0.41 | 5.68 | 1.48E-7 | Multiple sclerosis |
| THYM | cis | rs703842 | 1 | rs2072052 | chr12:58146719 | TSFM | chr12:58176536-58191367:+ | -0.26 | -4.6 | 1.29E-5 | Multiple sclerosis |
| THYM | cis | rs2239557 | 1 | rs2072293 | chr14:74537885 | LIN52 | chr14:74551656-74667117:+ | 0.38 | 7.07 | 2.63E-10 | Common traits (Other) |
| THYM | cis | rs2074038 | 1 | rs2074038 | chr11:44087989 | ACCS | chr11:44087475-44105569:+ | 1.06 | 8.64 | 1.32E-13 | IgA nephropathy |
| THYM | cis | rs757978 | 1 | rs2074771 | chr2:242350944 | SEPT2 | chr2:242254723-242293439:+ | 0.44 | 5.87 | 6.46E-8 | Chronic lymphocytic leukemia |